C-Reactive Protein (CRP), Plasma

 

Specimen requirement

Adult patient:

 

  Heparin gel tube

 

Minimum blood volume: 5 mL

Paediatric patient:

 

Paediatric heparin tube

 

Number of vials: 1

 

Minimum blood volume: 1.3 mL

Authorisation code required

No

24 Hr available service

Yes

 

(Call extension: 3353 for express result)

Method

Immunoassay

Reference interval

< 9.9 mg/L

 

(Source: from manufacturer's kit insert 2004 and concensus with peadiatricians)

Clinical indication

Assessment of acute phase reaction

Result interpretation

Elevation indicates acute phase response or active disease in chronic inflammatory disorders.

 

CRP is a more sensitive early indicator of an acute phase response than is the ESR. It also returns towards normal more rapidly with improvement or resolution of the disease process. The test is less sensitive than the ESR for some disorders e.g. ulcerative colitis, SLE.

Measurement of uncertainty

See table.

Frequency of measurement

Daily