Adult patient:
Clotted blood tube
(Serum gel separator clot activator tube)
Minimum blood volume: 5 mL
Paediatric patient:
Paediatric clotted blood tube
Number of vials: 1
Minimum blood volume: 0.8 mL
Authorisation code required
No
24 Hr available service
No
Method
Immunoassay
Reference interval
Serum Total IgA (Unit: g/L)
| Age | Male | Female |
| 0 to 3 months | 0.01 – 0.34 | 0.01 – 0.34 |
| > 3 months to 1 year | 0.08 – 0.91 | 0.08 – 0.91 |
| > 1 to 12 years | 0.21 – 2.91 | 0.21 – 2.82 |
| > 12 to 60 years | 0.63 – 4.84 | 0.65 – 4.21 |
| > 60 years | 1.01 – 6.45 | 0.69 – 5.17 |
Serum Total IgG (Unit: g/L)
| Age | Male | Female |
| 0 to 1 month | 3.97 – 17.7 | 3.91 – 17.4 |
| > 1 month to 1 year | 2.05 – 9.48 | 2.03 – 9.34 |
| > 1 to 2 years | 4.75 – 12.1 | 4.83 – 12.3 |
| > 2 years | 5.40 – 18.2 | 5.52 – 16.3 |
Serum Total IgM (Unit: g/L)
| Age | Male | Female |
| 0 to < 3 months | 0.06 – 0.21 | 0.06 – 0.21 |
| 3 months to 1 year | 0.17 – 1.43 | 0.17 – 1.50 |
| > 1 to 12 years | 0.41 – 1.83 | 0.47 – 2.40 |
| > 12 years | 0.22 – 2.40 | 0.33 – 2.93 |
(Source: from manufacturer’s kit inserts)
Clinical indication
Aids in the diagnosis of autoimmune diseases, sarcoidosis, chronic liver disease, chronic and recurrent infections, lymphoid malignancies, multiple myeloma and severe combined and variable immunodeficiencies.
Monitoring immunoglobulin levels in patients with multiple myeloma or chronic lymphocytic leukaemia
Result interpretation
Electrophoresis + immunofixation is required to exclude the presence of a paraprotein.
Normal immunoglobulin levels do not exclude humoral immunodeficiency.
Further studies, such as assessment of antibody response following administration of vaccines and / or IgG subclasses, may be required if there is a high degree of clinical suspicion.
Measurement of uncertainty
Frequency of measurement
Weekly