Luteinising Hormone (LH), Serum

 

Specimen requirement

Adult patient:

 

  Clotted blood tube (Serum gel separator clot activator tube)

 

Minimum blood volume: 5 mL

Paediatric patient:

Paediatric clotted blood tube

 

Number of vials: 2

 

Minimum blood volume: 1.6 mL

Authorisation code required

No

24 Hr available service

No

Method

Immunoassay

Reference interval

 

Male
< 30 days < 7.8 IU/L for nursing infants (boys & girls)
> 1 - 12 months < 0.4 IU/L
1 - 5 years < 1.3 IU/L
6 - 10 years < 1.4 IU/L
11 - 13 years < 7.8 IU/L
14 - 17 years 1.3 - 9.8 IU/L
> 17 years 1.7 - 8.6 IU/L
Female
< 30 days < 7.8 IU/L for nursing infants (boys & girls)
> 1 - 12 months < 0.4 IU/L
1 - 5 years < 0.5 IU/L
6 - 10 years < 3.1 IU/L
> 10 years Follicular phase:   2.4 - 12.6 IU/L
Ovulation phase:  14.0 - 95.6 IU/L
Luteal phase:        1.0 - 11.4 IU/L
Postmenopause:   7.7 - 58.5 IU/L

 

(Source: Product Information, Elecsys 1010 / 2010 / Modular Analytics E170 Roche Diagnostics)

Clinical indication

Investigation of male and female infertility to distinguish primary gonadal failure from pituitary / hypothalamic failure.

 

Identification of ovulation in the investigation of menstrual cycle disturbances and female infertility.

 

Suspected LH secreting pituitary tumour.

Result interpretation

High levels are found in primary gonadal failure.

 

Low levels occur with hypothalamic failure (responds to gonadotrophin releasing hormone) and pituitary failure (no response).

 

LH peak occurs just prior to, and identifies, ovulation.

 

Polycystic ovary syndrome is associated with an increased LH / FSH ratio.

Measurement of uncertainty

See table.

Frequency of measurement

Daily