Clotted blood tube (Serum gel separator clot activator tube)

Minimum blood volume: 5 mL

Paediatric clotted blood tube

Number of vials: 2

Minimum blood volume: 1.6 mL

< 115 kIU/L

(Source: from manufacturer's kit insert)

Aid in the diagnosis of autoimmune thyroid disease.

Aid in the assessment of interference from thyroglobulin autoantibodies to the thyroglobulin measurements.

Anti-thyroglobulin antibodies (ATGA) are often elevated in patients with Hashimoto thyroiditis. However, it is a less sensitive and less specific diagnostic marker of Hashimoto thyroiditis comparing with anti-thyroid peroxidase (TPO) antibodies.

ATGA may also be elevated in patients with Graves’ disease.

ATGA occur in low titre in 10% of healthy individuals without apparent thyroid disease.

Thyroglobulin (Tg) measurement is affected by the presence of ATGA, which can cause falsely low or high Tg result depending on the Tg method used.

Concentration of ATGA responds to changes in the mass of Tg-secreting thyroid tissue. Serial ATGA measurements can be used as a surrogate tumor marker test for ATGA-positive patients in whom Tg testing may be unreliable. A sustained increase in ATGA suggests an increased risk of disease recurrence. In contrast, patients who have persistent disease after treatment retain detectable ATGA concentrations. A rise in the ATGA level is often the first indication of recurrence in such patients.