Growth Hormone (GH), Serum

Specimen requirement Adult patient:

  Clotted blood tube (Serum gel separator clot activator tube)

Minimum blood volume: 5 mL

Paediatric patient:

Paediatric clotted blood tube

Number of vials: 2

Minimum blood volume: 1.6 mL

Authorisation code required No
24 Hr available service No
Method Immunoassay
Reference interval

(Unit: µg/L)

 

Serum Growth Hormone assay is calibrated against WHO second International Standard 98/574 (1 µg/L = 3 mIU/L)

See “Result interpretation” section.

Clinical indication

Investigations of pituitary and hypothalamic disorders causing growth abnormalities.

Diagnosis of acromegaly and assessment of treatment efficacy when interpreted in conjunction with results from glucose suppression test.

Diagnosis of growth hormone deficiency when interpreted in conjunction with results from growth hormone stimulation test.

Result interpretation

Growth hormone (GH) is released in a pulsatile manner. GH levels vary throughout the day and are influenced by multiple factors such as age, gender, sex hormones, glucose, amino acids, feeding, exercise, stress, body mass index, diurnal variation and medication. Random GH results are of limited diagnostic value and should be interpreted in conjunction with the patient's clinical presentation and other relevant laboratory findings.

GH samples should be collected as part of a stimulation or suppression test. Please refer to the corresponding dynamic function test protocol for result interpretation.

In general, serum IGF-1 is recommended for the diagnosis of GH excess and deficiency states as well as monitoring of GH replacement and suppression therapies.

Measurement of uncertainty See table.
Frequency of measurement 1 - 2 weeks