| Specimen requirement | Adult patient:
Minimum blood volume: 6 mL |
| Paediatric patient: Paediatric clotted blood tube (in ice bath) Number of vials: 2 Minimum blood volume: 1.6 mL |
|
| Authorisation code required | Yes (Private patient ONLY) |
| 24 Hr available service | No |
|
Precaution |
Fasting required.
Send in ice without delay. |
| Method | Immunoassay |
|
Reference interval |
0.9 - 7.1 µg/L
(Source: from manufacturer's kit insert)
Footnote: |
| Clinical indication |
Investigation of hypoglycaemia thought to be due to hyperinsulinism, particularly if surreptitious use of insulin is suspected. To assess pancreatic beta cell function and to distinguish type 1 from type 2 diabetes. |
| Result interpretation |
Pancreatic beta cells secrete C-peptide with insulin, so inappropriately high levels of insulin and C-peptide during hypoglycaemia indicate endogenous hyperinsulinism. Inappropriately high levels of insulin with low C-peptide during hypoglycaemia indicate exogenous hyperinsulinism. Pancreatic beta cells secrete C-peptide with insulin, so levels decline with beta cell failure. |
| Measurement of uncertainty | See table. |
| Frequency of measurement | 1 - 2 weeks |