C-Peptide, Serum  

Specimen requirement Adult patient:

  Clotted blood tube (Clot activator tube) (in ice bath)

Minimum blood volume: 6 mL

Paediatric patient:

Paediatric clotted blood tube (in ice bath)

Number of vials: 2

Minimum blood volume: 1.6 mL

Authorisation code required Yes

(Reserved test for restricted users or reflex test for indicated case)

24 Hr available service No

Precaution

Send in ice without delay.

Method Immunoassay

Reference interval

1.1- 4.4 µg/L (Fasting)

 

(Source: from manufacturer's kit insert)

 

Footnote:
C-Peptide level depends on factors such as pancreatic reserve, plasma glucose, state of fasting, etc. Please interpret C-Peptide with concurrent glucose and insulin results.

Clinical indication

To differentiate endogenous or exogenous source of hyperinsulinism in hypoglycemia.

To assess pancreatic beta cell function and to distinguish type 1 from type 2 diabetes.

Result interpretation

For insulin-mediated hypoglycemia, inappropriately high levels of insulin and C-peptide during hypoglycaemia indicate endogenous hyperinsulinism, while inappropriately high levels of insulin with low C-peptide during hypoglycaemia indicate exogenous hyperinsulinism.

Patients with type 1 diabetes would have low C-peptide, while type 2 diabetes would have detectable C-peptide.

Measurement of uncertainty See table.
Frequency of measurement 1 - 2 weeks