EDTA tube
Number of vials: 1
Minimum blood volume: 3 mL
Volume: 10 mL
24 Hr urine:
U1 bottle
Paediatric EDTA tube
Number of vials: 3
Minimum blood volume: 3.9 mL
Patient should sit for 15 min before and remain in sitting position during blood taking.
Refer to protocol for investigation of primary hyperaldosteronism (renin-aldosterone test) for patient preparations.
Plasma:
| Age | pmol/L | Source of Reference Intervals |
| 0 – < 30 days | < 6,025 | Quest Diagnostics Laboratory (LC/MS/MS method) |
| 30 days – < 1 year | 56 - 1,943 | |
| 1 – < 5 years | 56 - 1,027 | |
| 5 – < 10 years | < 250 | |
| 10 – < 14 years | < 583 | |
| 14 – < 18 years | < 972 | |
| ≥18 years | < 488 | Reference range established from local normotensive healthy subjects in sitting position for 15 min before and during blood taking |
24 Hr Urine:
2 - 38 nmol/day
(Source: local reference interval established from 126 normotensive healthy subjects)
Investigation of hypertension when primary hyperaldosteronism (Conn’s syndrome) is suspected, this is commonly but not invariably associated with hypokalaemia.
Documentation of hyperaldosteronism in the investigation of suspected renovascular hypertension.
The plasma aldosterone / renin ratio is of greater diagnostic value than either test alone.
A high aldosterone / renin ratio suggests a mineralocorticoid abnormality.
Elevation of both aldosterone and renin to a similar extent suggests a renal abnormality. The result should be interpreted in consultation with the pathologist.